However, more research is needed to compare the safety and efficacy of different artificial sweeteners. It may depend on your individual response and tolerance to different types of artificial sweeteners. However, some experts suggest that natural sweeteners derived from plants, such as stevia and monk fruit extracts, may have fewer side effects than synthetic ones, such as saccharin and aspartame34.
This may trigger the reward system in the brain and increase the desire for more sweet foods. Artificial sweeteners may also disrupt the signals that regulate hunger and satiety, leading to overeating and weight gain in some people13.īased on these potential side effects, it is hard to say which artificial sweetener has the least amount of side effects. Increased appetite and cravings for sweets: Artificial sweeteners may stimulate the taste receptors for sweetness without providing calories or satisfying hunger. Increased blood pressure: Artificial sweeteners may affect the production of nitric oxide, a molecule that helps relax blood vessels and lower blood pressure. This may increase the risk of hypertension and cardiovascular disease in some people2.Īdverse effects on mood: Artificial sweeteners may alter the levels of neurotransmitters, such as serotonin and dopamine, that affect mood and cognition. This may worsen symptoms of depression, anxiety, bipolar disorder, schizophrenia, and other mental health conditions in some people2. Higher risk of cancer: Some animal studies have suggested that artificial sweeteners, such as saccharin and aspartame, may increase the risk of bladder cancer, brain tumors, leukemia, and lymphoma. However, the evidence in humans is inconclusive and more research is needed to confirm the safety of artificial sweeteners12. Increased blood sugar levels: Artificial sweeteners may affect the balance of gut bacteria and hormones that regulate blood sugar and insulin sensitivity. This may lead to glucose intolerance, impaired glucose metabolism, and increased risk of type 2 diabetes in some people12.
However, based on my web search, some of the common side effects reported by some studies and experts are:ĭigestive issues: Artificial sweeteners may cause bloating, gas, cramps, pain, and diarrhea in some people, especially those with irritable bowel syndrome or other digestive disorders. This is because some artificial sweeteners, such as sugar alcohols, are fermented by bacteria in the colon12. The side effects of artificial sweeteners may vary depending on the type, the amount, and the individual.
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